I started watching Supernatural in the second season, when it was still on Tuesday night. I think they switched it to Thursday for season 3, so that "feels" like the right night. Honestly, it doesn't matter. I'll watch it no matter when/where it is, with very little getting in the way, and if I can't watch live, I'll DVR it to watch later.
But now they're moving our beloved show to Friday night, aka The Night Shows Go to Die. I know at least one person that is a problem for: she has a family night on Fridays, and is religious about it. Friday is "party" night, too, so ratings overall tend to be pretty low. Most shows that get moved to Friday don't last very long.
On the other hand, dying or being killed isn't a given, generally speaking. There have always been shows that did well on Friday, such as Providencetown and Numb3rs. Smallville kept its numbers the same after being moved to Friday, and it was always a good pairing with Supernatural (though I'd argue that The Vampire Diaries makes a better combo).
We hear a lot among "fandom" about how the CW doesn't give our show any love—doesn't promote it, doesn't support it, etc.—but after three years in a row of early pickups, and insisting it continue after a natural end point, I'd have to call bs on that complaint. Supernatural is a solid performer for them, and they struggle to develop new shows/enough programming for a full week.
So in my opinion, the move to Friday isn't necessarily a bad omen. In fact, I think we have to be more concerned about Ackles and Padalecki's contracts expiring this year.
What do you think?